Automated insulin delivery in young children with type 1 diabetes: a systematic review and meta-analysis.

materials_and_methods

Web of Science, PubMed, Scopus, CENTRAL, and ClinicalTrials.gov were searched from inception to December 9, 2025.

从创刊到2025年12月9日，对Web of Science、PubMed、Scopus、CENTRAL和ClinicalTrials.gov进行了搜索。

Studies reporting glycemic outcomes in children younger than 7 years were included in this meta-analysis.

本荟萃分析包括了报告7岁以下儿童血糖结果的研究。

Studies not published in English were excluded.

未用英文发表的研究被排除在外。

The primary outcome was the change in time-in-range (TIR; 70-180 mg/dL).

主要结果是时间在范围内（TIR; 70-180 mg/dL）的变化。

Pooled estimates were calculated using random-effects models and expressed as mean changes (MCs) with 95% confidence intervals (CIs).

使用随机效应模型计算了汇总估计值，并以平均变化（MCs）及其95%置信区间（CIs）表示。

Results

This study included 30 studies (9 randomized controlled trials, 7 single-arm studies, and 14 cohort studies) involving 1155 young children.

本研究纳入了30项研究（包括9项随机对照试验、7项单臂研究和14项队列研究），涉及1155名幼儿。

AID systems were associated with a significant increase in TIR (MC, 9.88% [95% CI 9.14 to 10.62], I2 = 8%, P < .0001, moderate certainty), equivalent to 2.37 hours/day.

自动胰岛素输送（AID）系统与时间在目标范围内（TIR）的显著增加相关（MC，9.88% [95% 置信区间 9.14 至 10.62]，I2 = 8%，P < .0001，中等确定性），相当于每天增加2.37小时。

Favorable improvement was also observed during the daytime (MC, 6.88% [95% CI 5.70 to 8.07]) and overnight (MC, 16.85% [95% CI 13.48 to 20.22]).

在白天期间也观察到了有利的改善（MC，6.88% [95% 置信区间 5.70至8.07]）和夜间（MC，16.85% [95% 置信区间 13.48至20.22]）。

TIR improvements were comparable across devices: MiniMed 670G (9.65%), MiniMed 780G (10.04%), CamAPS FX (10.58%), Control-IQ (9.51%), Omnipod 5 (10.25%), and Open Source (6.77%).

不同设备的TIR改善相当：MiniMed 670G（9.65%），MiniMed 780G（10.04%），CamAPS FX（10.58%），Control-IQ（9.51%），Omnipod 5（10.25%），开源（6.77%）。

AID use was also associated with reduced hyperglycemia exposure and modest reductions in glycated hemoglobin, without significant changes in hypoglycemia exposure.

AID的使用也与降低高血糖暴露和轻微降低糖化血红蛋白相关，而低血糖暴露没有显著变化。

Episodes of severe hypoglycemia and diabetic ketoacidosis were infrequent.

严重低血糖和糖尿病酮症酸中毒的发作次数较少。

Conclusions

This systematic reviewwith meta-analysisrevealed that AID systems have greater benefits for improving glycemic outcomes and have good safety profiles in young children with type 1 diabetes.

这项系统评价和荟萃分析显示，自动胰岛素输送系统在改善年轻1型糖尿病儿童的血糖结果方面具有更大的益处，并且具有良好的安全性。