Long-acting growth hormone for treating growth hormone deficiency in children: a meta-analysis of randomized controlled trials focusing on changes in body mass index.

Methods

We searched the PubMed database from its inception to July 2025 and identified three relevant randomized controlled trials lasting over 6 months, with extension phases providing longitudinal BMI data.

我们在PubMed数据库中从创建之初到2025年7月进行了搜索，确定了三项持续超过6个月的相关随机对照试验，并且这些试验的扩展阶段提供了纵向的BMI数据。

Longitudinal BMI data were available for lonapegsomatropin, somatrogon, and somapacitan, but not for polyethylene glycol LAGH.

长期体重指数（BMI）数据可用于lonapegsomatropin、somatrogon和somapacitan，但无法用于聚乙二醇LAGH。

Results

A total of 585 patients were included in the present analysis, of which 346 were in the LAGH group, and 239 were in the daily rhGH group, derived from seven original articles and two abstracts/ePosters.

本分析共纳入585名患者，其中346名在LAGH组，239名在每日重组人生长激素（rhGH）组，数据来源于七篇原创文章和两篇摘要/电子海报。

At 12 months, there was a significant difference in BMI SD scores between LAGH and daily GH groups (Mean difference [MD] 0.66 SDS [95% confidence interval[CI] 0.04-1.29]).

在12个月时，LAGH组和每日GH组之间的BMI标准差分数存在显著差异（平均差异[MD] 0.66 SDS [95%置信区间[CI] 0.04-1.29]）。

BMI SDS significantly increased in the LAGH group (MD + 0.41 SDS [95% CI 0.04-0.77] from 0 to 12 months), whereas it did not change in the daily GH group (MD -0.35 SDS [95% CI -0.76 to +0.07] from 0 to 12 months).

在LAGH组中，BMI SDS显著增加（从0到12个月的平均差异[MD] +0.41 SDS [95%置信区间[CI] 0.04-0.77]），而在每日GH组中，BMI SDS没有变化（从0到12个月的平均差异[MD] -0.35 SDS [95%置信区间[CI] -0.76到+0.07]）。

Between 12 and 24 months, after switching from daily GH to LAGH (daily GH/LAGH), or pursuing LAGH (LAGH/LAGH) in the extension phases of the studies, BMI SDS significantly increased in the daily GH/LAGH switching group (MD + 0.75 SDS [95% CI 0.24-1.27] from 12 to 24 months), whereas it remained steady in the LAGH/LAGH group.

在12至24个月期间，研究的扩展阶段中，从每日生长激素（GH）转换为长效生长激素（LAGH）（每日GH/LAGH），或继续使用LAGH（LAGH/LAGH）后，每日GH/LAGH转换组的BMI SDS显著增加（MD + 0.75 SDS [95% CI 0.24-1.27]从12个月到24个月），而LAGH/LAGH组保持稳定。

Omitting one study at a time from the meta-analysisdid not materially affect the results.

每次从荟萃分析中排除一项研究，结果并未实质性改变。

Conclusions

An increase in body mass index SD score is associated with the first year of LAGH use.

使用长效生长激素(LAGH)的第一年，体质指数标准差得分的增加与之相关。

Results

Omitting one study at a time from the meta-analysisdid not materially affect the results.

每次从荟萃分析中排除一项研究，结果并未实质性改变。