The effect of hypercortisolism treatment on dyslipidemia in Cushing syndrome: systematic review and meta-analysis.

Among the metabolic effects of CS and its treatment, glycemic disturbances have been investigated in depth, while data on dyslipidemia is still lacking.

在CS及其治疗的代谢效应中，对血糖紊乱进行了深入研究，而关于血脂异常的数据仍然缺乏。

Background

Our study aims at evaluating the effects of CS treatment on serum lipid levels.

我们的研究旨在评估CS治疗对血清脂质水平的影响。

materials_and_methods

A literature search was conducted using PubMed, Scopus, and EMBASE databases to investigate the effects of CS treatment on serum total cholesterol (TC), low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides.

我们使用PubMed、Scopus和EMBASE数据库进行了文献检索，以研究CS治疗对血清总胆固醇（TC）、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯的影响。

Before-after analysis and subgroup analysis were performed.

进行了前后对比分析和亚组分析。

Results

Twenty-nine observational or interventional studies (51.7% of good quality) were included in the quantitative analysis.

定量分析中包括了29项观察性或干预性研究（其中51.7%为高质量研究）。

Treatment of CS led to clinically and statistically significant decrease in serum TC (mean difference [MD] -26.49; 95% CI, -29.95 to -23.04; P < .00001), low-density lipoprotein cholesterol (MD -18.44; 95% CI, -21.30 to -15.57; P < .00001), and triglycerides levels (MD -17.77; 95% CI, -22.70 to -12.84; P < .00001), with no significant changes in high-density lipoprotein cholesterol levels (MD -2.34; 95% CI, -6.96 to 2.28; P = .32).

CS的治疗导致血清总胆固醇（平均差异[MD] -26.49; 95% 置信区间, -29.95 至 -23.04; P < .00001）、低密度脂蛋白胆固醇（MD -18.44; 95% CI, -21.30 至 -15.57; P < .00001）和甘油三酯水平（MD -17.77; 95% CI, -22.70 至 -12.84; P < .00001）的临床和统计学显著降低，而高密度脂蛋白胆固醇水平没有显著变化（MD -2.34; 95% CI, -6.96 至 2.28; P = .32）。

Subgroup analysis showed greater decrease in TC levels in subjects with adrenal hypercortisolism, in those treated with steroidogenesis inhibitors, and in those with treatment duration ≥12 months.

亚组分析显示，肾上腺皮质功能亢进患者、接受类固醇生成抑制剂治疗的患者以及治疗持续时间≥12个月的患者的总胆固醇水平降低更为显著。

In addition, CS treatment significantly decreased blood glucose levels, body mass index, waist circumference, and insulin resistance index.

此外，CS治疗显著降低了血糖水平、体重指数、腰围和胰岛素抵抗指数。

Conclusions

Our study demonstrates a significant improvement in serum lipid levels after treatment of CS.

我们的研究表明，在CS治疗后，血清脂质水平有显著改善。

Because the cardiovascular complications of hypercortisolism depend on several factors, further studies are needed to determine whether this directly translates into an adequate reduction in the risk of major cardiovascular events.

由于高皮质醇血症引起的心血管并发症取决于多个因素，因此需要进一步的研究来确定这是否直接转化为主要心血管事件风险的适当降低。