Estimates of Incidence and Prevalence of Conversions to Mild Cognitive Impairment and Dementia in Patients With Essential Tremor.

However, studies of the prevalence, incidence, and annual conversion proportions to mild cognitive impairment (MCI) and dementia are based on limited data, and results are heterogeneous.

然而，关于其患病率、发病率以及每年转变为轻度认知障碍（MCI）和痴呆的比例的研究基于有限的数据，且结果不一。

Methods

Older individuals with ET were enrolled in a prospective longitudinal study of cognitive function.

招募了年龄较大的真性红细胞增多症(ET)患者参与了一项前瞻性纵向认知功能研究。

Recruitment was national, and participants resided in 43 states.

该研究的招募是全国性的，参与者居住在43个州。

Extensive neuropsychological testing was conducted during home visits at baseline and again during follow-up visits at 18, 36, 56, 72, and 90 months (M years of observation = 4.7 years, maximum = 7.5 years).

在基线时以及随访时（分别在18、36、56、72和90个月时）进行了广泛的神经心理测试（观察年数的平均值为4.7年，最大值为7.5年）。

Participants were assigned a cognitive diagnosis of normal cognition (NC), MCI, or dementia by expert consensus based on the detailed assessments conducted during each visit.

根据每次访问期间进行的详细评估，参与者被专家共识分配为认知正常（NC）、轻度认知障碍（MCI）或痴呆症的认知诊断。

Prevalence, incidence, and annual conversion proportions to MCI and dementia were calculated.

计算了轻度认知障碍(MCI)和痴呆症的患病率、发病率以及每年的转化比例。

We also performed a systematic reviewof the relevant literature followed by a meta-analysisto derive pooled estimates of prevalence, incidence, and annual conversion proportions for comparison purposes.

我们还对相关文献进行了系统综述，并进行了荟萃分析，以得出患病率、发病率和每年转化比例的汇总估计值，用于比较目的。

Results

There were 350 participants, M baseline age = 79.6 years, 60.6% female.

共有350名参与者，基线平均年龄为79.6岁，女性占60.6%。

Cumulative prevalences of MCI and dementia were 22.0% (95% confidence interval[CI] = 18.0-26.6) and 14.6% (95% CI = 11.3-18.7), cumulative incidences were 12.9% (95% CI = 9.3-17.6) and 10.2% (95% CI = 7.2-14.2), respectively, and the average annual proportion of conversions from MCI to dementia was 13.8%.

轻度认知障碍（MCI）和痴呆的累积患病率分别为22.0%（95%置信区间[CI] = 18.0-26.6）和14.6%（95% CI = 11.3-18.7），累积发病率分别为12.9%（95% CI = 9.3-17.6）和10.2%（95% CI = 7.2-14.2），平均每年从MCI转化为痴呆的比例为13.8%。

Pooled estimates of these values were derived from meta-analyses of our data and existing studies of ET cohorts, general population cohorts, and Parkinson disease (PD) cohorts.

这些值的汇总估计是通过对我们数据和现有ET队列、普通人群队列以及帕金森病（PD）队列的元分析得出的。

The burden of MCI and dementia in ET was overall substantially higher than that observed in the general population yet lower than that seen in PD.

ET中轻度认知障碍（MCI）和痴呆的负担总体上显著高于普通人群观察到的水平，但低于PD中观察到的水平。

Discussion

The data document the longitudinal trajectory of cognitive impairment in ET in the largest available sample to date.

数据记录了迄今为止最大样本集中ET患者认知障碍的纵向轨迹。

Whether considered as stand-alone results, or when combined with data from the extant literature, the occurrence of MCI and dementia in ET is higher than observed in same age members of the general population, but is less pronounced than observed in same aged individuals with PD.

无论是作为独立结果考虑，还是与现有文献数据结合，ET患者中轻度认知障碍（MCI）和痴呆的发生率都高于同龄普通人群，但低于同龄帕金森病（PD）患者。