Prevalence of CKD Among Adults in Africa: A Systematic Review and Meta-Analysis.

This study estimated CKD prevalenceacross the African continent.

本研究估计了非洲大陆上CKD的患病率。

study_design

Systematic reviewand individual participant data meta-analysis.

系统评价和个体患者数据荟萃分析。

SETTING & STUDY POPULATION: Populations residing in Africa.

研究设置与研究人群：居住在非洲的人群。

selection_criteria

Eligible studies enrolled ≥300 adults, were observational, used community-based designs, and reported CKD prevalenceor data necessary to calculate it.

符合条件的研究招募了≥300名成年人，是观察性的，使用了基于社区的设计，并报告了慢性肾脏病（CKD）的患病率或计算所需的数据。

search_strategy

Studies, both published and unpublished, through May 31, 2024, identified through systematic searches of major databases and through networks within the CKD-Africa Collaboration.

通过系统性搜索主要数据库和CKD-Africa协作网络中的网络，确定了截至2024年5月31日的已发表和未发表的研究。

data_extraction

Data were systematically extracted and verified by the authors.

数据由作者系统地提取并验证。

Extracted information included study and publication details, CKD diagnostic criteria, and participant characteristics.

提取的信息包括研究和出版细节、慢性肾脏病（CKD）的诊断标准以及参与者的特征。

analytical_approach

Pooled prevalenceestimates were calculated using random-effects meta-analysis.

使用随机效应元分析计算了汇总的患病率估计值。

Results

Sixty-seven studies, comprising 91,723 participants from 19 countries, were included.

包括来自19个国家的67项研究，共有91,723名参与者。

High- and moderate-quality studies accounted for 37% and 52%, respectively, and 6% were unpublished.

高质量和中等质量的研究分别占37%和52%，未发表的研究占6%。

Pooled CKD prevalence(stages 1-5) was 13.7% (95% CI, 11.0-16.4), and 5.1% (95% CI, 4.3-5.8) for stages 3-5.

综合慢性肾脏病（CKD）的患病率（1-5期）为13.7%（95%置信区间，11.0-16.4），3-5期的患病率为5.1%（95%置信区间，4.3-5.8）。

Regional variation was evident (I2 >98%; P < 0.001), with higher prevalencein western Africa compared to southern Africa.

地区差异明显（I2 >98%；P < 0.001），西非的患病率高于南非。

Estimates using aggregated data and individual participant data were consistent.

使用汇总数据和个体参与者数据得出的估计结果是一致的。

limitations

Variations in the quality of the study data and substantial heterogeneity in prevalenceestimates.

研究数据质量的差异以及患病率估计中的显著异质性。

Lack of assessment of chronic CKD.

缺乏对慢性慢性肾脏病(CKD)的评估。

Reliance on aggregated data for 55% of the sample.

55%的样本依赖于聚合数据。

Gaps in geographic representation may limit the generalizability of findings.

地理代表性上的缺口可能会限制研究发现的普遍适用性。

Conclusions

Approximately 14% of African adults had CKD, highlighting its public health burden.

大约14%的非洲成年人患有慢性肾脏病（CKD），凸显了其公共卫生负担。

The precision of this finding was augmented by the use of individual participant data.

通过使用个体参与者数据，这一发现的精确度得到了增强。

registration

Registered at Prospero with identification number CRD42019143370.

已在Prospero注册，识别编号为CRD42019143370。

PLAIN-LANGUAGE SUMMARY: Chronic kidney disease (CKD), a long-term condition in which the kidneys gradually lose their ability to filter waste and fluids from the blood, is an increasing health problem in Africa, but prevalencedata have been limited.

简易语言摘要：慢性肾脏病（CKD），一种长期疾病，肾脏逐渐丧失过滤血液中废物和液体的能力，在非洲是一个日益严重的健康问题，但流行病学数据有限。

Previous studies relied on only summaries of studies' data.

先前的研究仅依赖于研究数据的汇总。

This analysis combined individual-level and summary data from multiple African countries to provide a more accurate and precise estimate of CKD prevalence.

本分析结合了来自多个非洲国家的个体水平数据和汇总数据，以提供一个更准确和精确的慢性肾脏病（CKD）患病率估计。

It found that CKD affects a substantial proportion of adults, with rates varying across regions.

研究发现，慢性肾脏病（CKD）影响了相当比例的成年人，不同地区的发病率有所不同。

These findings highlight the potential value of early detection given the availability of effective clinical strategies to manage CKD.

这些发现强调了早期检测的潜在价值，鉴于目前有有效的临床策略来管理CKD。