Genome-wide donor-recipient non-HLA mismatch and graft loss.

Recent findings suggest that donor-to-recipient mismatches outside the HLA region contribute to alloimmunity and graft loss, but the extent varies in different publications.

最近的研究表明，HLA区域外的供体与受体不匹配会促进异体免疫和移植器官丢失，但不同出版物中这种影响的程度有所不同。

We therefore conducted a systematic reviewof publications on this subject using a broad search string in our literature review in accordance with current guidelines for systematic reviews.

因此，我们根据系统评价的现行指南，使用广泛的搜索词在文献综述中进行了关于这一主题的系统评价。

The effect sizes were analyzed by a meta-analysis.

通过荟萃分析分析了效应量。

A total of 1890 publications from 2019-25 within three different repositories (465 Medline, 1408 Embase, 17 Central) were systematically screened using the PICOTS (Population, Intervention, Comparator, Outcome, Time and Setting) system, which resulted in 12 eligible papers that met the inclusion criteria.

在2019至2025年间，从三个不同的数据库（Medline 465篇，Embase 1408篇，Central 17篇）中系统筛选了总计1890篇出版物，使用PICOTS（人群、干预、对照、结果、时间和设置）系统，最终确定了12篇符合纳入标准的合格论文。

Cohort studies that investigated the association of D-R non-HLA SNP mismatch and graft rejection/loss in renal transplant patients were included.

纳入了研究D-R非HLA SNP不匹配与肾移植患者移植排斥/丢失关联的队列研究。

We found that overall SNP mismatch between D-R pairs outside the HLA region was independently numerically associated with rejection hazard ratio(HR) 1.26 [95% confidence interval(CI) 0.97-1.65] and graft loss HR 1.35 (95% CI 0.86-2.12).

我们发现，HLA区域外供体-受体(D-R)对之间SNP不匹配的总体差异与排斥反应的危险比(HR)独立数值相关，为1.26 [95%置信区间(CI) 0.97-1.65]，以及移植物损失的HR为1.35 (95% CI 0.86-2.12)。

Furthermore, loss of function mutation of the gene LIMS1 in the recipient who received a transplant organ with at least one functioning copy (collision genotype) was numerically associated with rejection HR 1.23 (95% CI 0.68-2.23) and graft loss HR 1.43 (95% CI 0.61-3.36).

此外，接受至少有一个功能拷贝的移植器官的受体中，LIMS1基因的失活突变与排斥反应的危险比(HR)数值相关，为1.23 (95% CI 0.68-2.23)，以及移植物损失的HR为1.43 (95% CI 0.61-3.36)。

The exact quantification of the effect size of these mismatches varied by publication and needs further investigation.

这些不匹配的效果大小的确切量化因出版物而异，需要进一步研究。

Based on these data, the strength of immunosuppression may be guided by the load of D-R mismatches in the future.

基于这些数据，未来的免疫抑制强度可能会根据供体-受体(D-R)不匹配的负荷来指导。