Consensus recommendations for CAR T-cell administration in adult acute lymphoblastic leukemia: a modified Delphi study.

Several key clinical questions related to best practices for CAR T-cell administration in this population exist, and limited prospective randomized trials have been conducted to fill these knowledge gaps.

与此人群中CAR T细胞应用的最佳实践相关的几个关键临床问题仍然存在，而有限的前瞻性随机试验已经进行，以填补这些知识空白。

Thus, to help guide clinical practice, we conducted a modified Delphi study to develop and validate consensus recommendations on the administration of commercially available CAR T-cell therapy for adults with B-ALL.

因此，为了帮助指导临床实践，我们进行了一项改良的德尔菲研究，以制定和验证关于为成年B-ALL患者使用商业上可获得的CAR T细胞疗法的共识建议。

Consensus panelists (n = 9) included principal investigators (PIs) from Real World Outcomes Collaborative of CAR T-Cell Therapy in Adult ALL (ROCCA) consortium sites and were selected based on expertise and CAR T-cell center volume.

共识小组成员（n = 9）包括来自成人ALL CAR T细胞疗法真实世界结果协作联盟（ROCCA）联盟站点的主要研究员（PIs），并根据专业知识和CAR T细胞中心的容量进行选择。

Final panel consensus recommendations were distributed for rating by the remaining PIs from ROCCA consortium sites, which served as the validation group (n = 27).

最终的专家小组共识建议被分发给ROCCA联盟站点的剩余PIs进行评分，这些PIs作为验证组（n = 27）。

Consensus topics included patient selection, bridging and pre-CAR T-cell leukemia staging, lymphodepletion, and CAR T-cell treatment setting, specific toxicity prevention and management, post-CAR T-cell response assessment and disease monitoring, and the role of consolidation and/or maintenance therapies after CAR T-cell therapy.

共识主题包括患者选择、桥接和CAR T细胞治疗前的白血病分期、淋巴耗竭、CAR T细胞治疗设置、特定的毒性和管理、CAR T细胞治疗后的反应评估和疾病监测，以及CAR T细胞治疗后巩固和/或维持治疗的作用。

Initially, 58 recommendation statements were evaluated for consensus.

最初，共有58条推荐声明被评估以达成共识。

After 2 panel meetings, a total of 34 statements achieved consensus rating among the expert panel.

经过2次专家组会议后，专家组中总共有34条声明达到了共识评级。

After rating by the validation group, all but 1 recommendation statement continued to meet consensus, for a total of 33 consensus recommendation statements on the administration of CAR T-cell therapy in adult B-ALL.

经过验证组的评分后，除了1条建议声明外，其余均继续满足共识，总共形成了33条关于成人B-ALL中CAR T细胞疗法应用的共识建议声明。