Cortisol in sickle cell disease: a systematic review and meta-analysis.

This review aimed to systematically evaluate the current literature for cortisol measurement and methodology among individuals with SCD and synthesize findings of biopsychosocial correlates in this population.

本综述旨在系统评估镰状细胞病患者中皮质醇测量和方法学的当前文献，并综合这一人群生物心理社会相关性的发现。

A systematic search of medical databases was conducted, resulting in 20 studies meeting inclusion criteria, involving 710 participants with SCD and 454 control participants without SCD.

进行了医学数据库的系统检索，共纳入了20项研究，这些研究包括710名患有镰状细胞病（SCD）的参与者和454名没有镰状细胞病的对照参与者。

Cortisol was primarily measured using serum (k = 10) and plasma (k = 8), and few studies used salivary (k = 1) or hair (k = 1) measurements.

皮质醇主要通过血清（k = 10）和血浆（k = 8）进行测量，少数研究使用唾液（k = 1）或头发（k = 1）进行测量。

Most studies investigated cortisol in comparison with a control group (k = 14).

大多数研究将皮质醇与对照组进行了比较（k = 14）。

Qualitative findings were inconsistent, and quantitative meta-analytic data (k = 12) imply no significant difference in cortisol in SCD participants relative to healthy controls (serum Hedges g = -1.51, 95% confidence interval[CI], -3.99 to 0.97; plasma Hedges g = -0.72; 95% CI, -1.56 to 0.13).

定性结果不一致，而定量的荟萃分析数据（k = 12）表明，与健康对照组相比，SCD参与者的皮质醇没有显著差异（血清Hedges g = -1.51，95%置信区间[CI]，-3.99至0.97；血浆Hedges g = -0.72；95% CI，-1.56至0.13）。

Additionally, studies examined cortisol in comparison with adrenal standards (k = 5), responses to adrenocorticotropic hormone stimulation (k = 7), and correlations with vaso-occlusive crises (k = 3) and disease severity (k = 3).

此外，研究比较了皮质醇与肾上腺标准（k = 5），对促肾上腺皮质激素刺激的反应（k = 7），以及与血管阻塞性危象（k = 3）和疾病严重程度（k = 3）的相关性。

Few studies explored medication (k = 2) or behavioral correlates (k = 1) of cortisol.

少数研究探讨了皮质醇的药物（k = 2）或行为相关性（k = 1）。

Finally, no study investigated the influence of psychosocial stressors on cortisol levels.

最后，没有研究调查心理社会压力因素对皮质醇水平的影响。

There is a clear need for high-quality observational research to clarify cortisol findings in SCD and identify psychosocial correlates and biomedical outcomes.

迫切需要高质量的观察性研究来阐明镰状细胞病（SCD）中皮质醇的发现，并识别心理社会相关因素和生物医学结果。