The evolving nosology of myeloid neoplasms: the semi-centennial of the 1976 French-American-British classification.

Bennett and colleagues.

贝内特及其同事。

The FAB classification of acute leukemia formed the biological framework of our current understanding of myeloid neoplasia.

急性白血病的FAB分类构成了我们当前对骨髓增殖性疾病生物学理解的基础框架。

Reflecting from this historical lens, we have seen remarkable advances in diagnostics, prognostication, and therapeutics over the decades.

回顾历史，我们见证了数十年来在诊断、预后评估和治疗方面的显著进步。

Concerted efforts from various consensus groups have paved the way for these advances.

来自各种共识小组的共同努力为这些进步铺平了道路。

Herein, we perform a historical analysis of the evolution of the nosology of myeloid neoplasms over the past 50 years, beginning with the landmark 1976 FAB classification.

在这里，我们对过去50年髓系肿瘤命名法的演变进行了历史分析，从1976年的FAB分类开始。

We discuss how the new nosology of myeloid neoplasms has been inspired by the widespread availability of next-generation sequencing technology as a critical adjunct to classical morphological assessment.

我们讨论了新的髓系肿瘤分类是如何受到下一代测序技术广泛可用性的启发，作为经典形态学评估的关键辅助。

We discuss evidence in support of a conceptual framework for categorizing myeloid neoplasms based on ontogeny, beginning from clonal hematopoiesis of indeterminate potential (CHIP).

我们讨论了支持基于发生学对髓系肿瘤进行分类的概念框架的证据，从不确定潜能的克隆性造血（CHIP）开始。

We review the foundational definitions of CHIP, including parallels with Darwinism at the cellular level, and the relevance of incorporation of precursor conditions into the most recent disease classification of myeloid neoplasms.

我们回顾了CHIP（克隆性造血）的基础定义，包括在细胞水平上与达尔文主义的相似之处，以及将前体条件纳入最新髓系肿瘤疾病分类的相关性。

We shed light onto patient-focused practical implications of classification schema, with emphasis on mutation-adapted therapeutic strategies.

我们阐明了分类方案对患者的实际意义，重点强调了基于突变的治疗策略。

Finally, we discuss how emerging techniques such as single-cell sequencing and multi-omics may integrate into future revisions.

最后，我们讨论了单细胞测序和多组学等新兴技术如何整合到未来修订中。