MPN-FIT: a randomized controlled pilot trial of supervised exercise in myeloproliferative neoplasms.

Physical activity has demonstrated benefits in other cancers; however, its potential has yet to be explored in MPN.

在其他癌症中，身体活动已显示出益处；然而，其在MPN中的潜力尚未被探索。

This randomized controlled trialaimed to evaluate the feasibility, acceptability, and efficacy of a supervised exercise program for patients with MPN based on longitudinal assessment of symptom burden, QoL, and clinical/inflammatory markers (C-reactive protein, erythrocyte sedimentation rate, ferritin, lactate dehydrogenase [LDH], and serum cytokines).

这项随机对照试验旨在评估基于症状负担、生活质量以及临床/炎症标志物（C反应蛋白、红细胞沉降率、铁蛋白、乳酸脱氢酶[LDH]和血清细胞因子）的纵向评估，对骨髓增殖性肿瘤(MPN)患者进行监督运动计划的可行性、可接受性和有效性。

Patients with MPN (n = 55) were randomized 3:2 to a 12-week home-based exercise intervention (flexibility/resistance/aerobics) supervised by a kinesiologist vs waitlist control.

55名MPN患者按3:2的比例随机分为12周的家庭运动干预组（包括柔韧性/抗阻/有氧运动），由运动生理学家监督，与等待名单对照组进行比较。

Measures included patient-reported outcome questionnaires, peripheral blood sampling, and postintervention interviews with participants.

测量内容包括患者报告的结果问卷、外周血采样以及与参与者的干预后访谈。

Forty-seven patients completed the trial (FIT group, n = 26; control group, n = 21).

47名患者完成了试验（FIT组，n=26；对照组，n=21）。

Median age was 66 years (range, 27-86), and 60% were female.

中位年龄为66岁（范围，27-86岁），女性占60%。

All feasibility benchmarks were met, with 88% of participants satisfied and 92% with intent to continue an exercise program on a regular basis.

所有可行性基准均得到满足，88%的参与者表示满意，92%的人有意定期继续进行锻炼计划。

A significant reduction in LDH was observed in FIT patients compared with controls (-14.5 U/L vs +4.0 U/L; P = .03).

与对照组相比，FIT患者观察到乳酸脱氢酶（LDH）显著降低（-14.5 U/L vs +4.0 U/L; P = .03）。

Patients interviewed described positive effects of the intervention on symptoms and would unanimously recommend the program to others with MPN.

接受访谈的患者描述了干预措施对症状的积极影响，并且会一致推荐该计划给其他患有骨髓增殖性肿瘤（MPN）的人。

In this pilot study, supervised exercise was feasible, acceptable, and showed potential benefits on inflammatory/disease markers.

在这项初步研究中，监督下的运动是可行的、可接受的，并显示出对抗炎/疾病标志物的潜在益处。