Pilot study of an inpatient physical activity intervention for older adults treated intensively for acute myeloid leukemia.

We tested the feasibility of a randomized physical activity (PA) intervention among older adults (aged ≥60 years) receiving induction chemotherapy for newly diagnosed AML, and estimated the effect on physical function, quality of life (QOL), and symptoms.

我们在接受诱导化疗的新诊断AML老年患者（年龄≥60岁）中测试了随机体育活动（PA）干预的可行性，并估计了其对身体功能、生活质量（QOL）和症状的影响。

Intervention participants were offered PA sessions 5 days per week, tailored daily to symptoms during the induction hospitalization, along with weekly behavioral counseling sessions that continued monthly by phone for 6 months.

干预参与者在诱导住院期间每天根据症状接受5天一次的PA（身体活动）课程，并在接下来的6个月内每周接受一次行为咨询课程，之后每月通过电话继续进行咨询。

The primary outcome was feasibility (recruitment, retention, and participation).

主要结果是可行性（招募、留存和参与度）。

The key secondary outcome of interest was the Short Physical Performance Battery (SPPB).

关注的主要次要结果是短体能表现电池（SPPB）。

SPPB score was assessed at baseline, weekly during hospitalization, and at 3 and 6 months.

SPPB评分在基线时、住院期间每周以及3个月和6个月时进行了评估。

Among 96 eligible patients, 70 enrolled (mean age, 72.1 ± 6.3 years [range, 60-88]).

在96名符合条件的患者中，有70名患者参与了研究（平均年龄72.1 ± 6.3岁[范围，60-88]）。

Primary feasibility targets were met, with a recruitment rate of 72%, adherence of 74%, and average participation of 3 sessions per week.

主要的可行性目标已经达成，招募率为72%，依从性为74%，平均每周参与3次会话。

Among survivors, the retention rates were 96% and 95% at 3 (n = 51/53) and 6 (n = 42/44) months, respectively.

在幸存者中，3个月（n = 51/53）和6个月（n = 42/44）的保留率分别为96%和95%。

In exploratory analyses, SPPB scores were maintained or improved in 38% of intervention participants vs 25% of controls at end of induction (n = 66; P = .21).

在探索性分析中，SPPB评分在诱导结束时（n = 66；P = .21）在38%的干预参与者中保持或改善，而对照组为25%。

There were no differences between groups in QOL or symptoms.

两组在生活质量或症状方面没有差异。

A PA intervention with behavioral counseling during induction was feasible for older adults receiving intensive therapy for AML.

在诱导治疗期间，为接受AML强化治疗的老年患者提供行为咨询的PA干预是可行的。

This trial was registered at www.ClinicalTrials.gov as #NCT01519596.

该试验已在www.ClinicalTrials.gov上注册，注册号为#NCT01519596。