Estimating the annual number of hepatitis C virus infections through vertical transmission at country, regional, and global levels: a data synthesis study.

Studies have estimated that 7-12% of children born to women with HCV infection will acquire HCV, although around two-thirds of children will then clear their HCV infection by 5 years of age.

研究估计，HCV感染的妇女所生儿童中有7-12%会获得HCV，尽管大约三分之二的儿童在5岁前会清除其HCV感染。

We aimed to estimate the annual number of vertically transmitted HCV infections and how many cases remain at 5 years of age at the country or territory, regional, and global levels.

我们旨在估计每年垂直传播的丙型肝炎病毒（HCV）感染数量以及在国家或地区、区域和全球层面上，有多少病例在5岁时仍然存在。

Methods

In this data synthesis study, we produced estimates of vertical HCV transmission by combining data from several sources: data on the number of women, age-specific fertility rates, mortality rates among children aged 0-5 years, and HIV prevalenceamong women aged 15-49 years from the UN; modelled data on HCV prevalenceamong women aged 15-49 years; meta-analysisdata on HCV-HIV co-infection prevalence; and recent estimates of the probabilities of vertical HCV transmission and subsequent clearance by age 5 years.

在这项数据综合研究中，我们通过结合来自多个来源的数据来估算垂直传播的HCV：联合国关于15-49岁女性数量、年龄特定生育率、0-5岁儿童死亡率的数据；15-49岁女性HCV感染率的模型数据；HCV-HIV共感染率的荟萃分析数据；以及最近的垂直传播HCV的概率以及5岁时的清除率的估算。

The annual number of births with HCV was estimated by multiplying the number of women with HCV in 5-year age bands by age band-specific birth rates, separately by HIV status, and multiplying by HIV status-specific HCV vertical transmission probabilities.

通过将具有HCV的女性按5岁年龄组的数量乘以各年龄组特定的生育率，分别按HIV状态计算，并乘以HIV状态特定的HCV垂直传播概率，估算每年带有HCV的出生数。

The number of births with HCV was multiplied by the probability of spontaneous clearance of HCV by 5 years of age, accounting for mortality.

将带有HCV的出生数乘以5岁时HCV自发清除的概率，同时考虑死亡率。

All estimates were sampled 1000 times from their uncertainty intervals (UIs) to produce 95% UIs.

所有估计值都是从其不确定性区间(UIs)中抽样1000次以产生95%的UIs。

Results

The estimated annual global number of new HCV infections occurring through vertical transmission was 73 862 (95% UI 69 808-78 279).

估计的每年全球通过垂直传播的新发HCV感染数为73,862例（95% UI 69,808-78,279）。

Southern Asia (21 245 [18 095-24 847]), western Africa (16 482 [14 873-18 283]), and eastern Africa (8182 [7479-9085]) were the regions with the most infections.

南亚(21 245 [18 095-24 847])、西非(16 482 [14 873-18 283])和东非(8182 [7479-9085])是感染病例最多的地区。

Pakistan (16 350 [13 325-19 844]) and Nigeria (8483 [6944-10 184]) had the largest burden and together accounted for around a third of new infections.

巴基斯坦(16 350 [13 325-19 844])和尼日利亚(8483 [6944-10 184])的负担最重，两者合计约占新发感染病例的三分之一。

We estimated that 23 120 (20 596-25 813) of these children would be alive and still have HCV when aged 5 years.

我们估计，当这些儿童5岁时，将有23,120人（95%置信区间20,596-25,813）仍然存活并携带丙型肝炎病毒（HCV）。

interpretation

Targeted screening policies that test and treat pregnant women with HCV could prevent substantial numbers of new HCV infections; however, data on the safety of HCV treatments in pregnant women are required.

针对孕妇进行丙型肝炎病毒（HCV）检测和治疗的靶向筛查政策可以预防大量新的HCV感染；然而，需要有关孕妇使用HCV治疗的安全性数据。

funding

None.

无。