Motivational interviewing and air cleaners for smokers with COPD (MOVE): a randomized, double-blind, placebo-controlled trial.

It is unclear if reducing indoor pollutants can improve respiratory health among current smokers.

尚不清楚减少室内污染物是否能改善当前吸烟者的呼吸健康。

Background

This study aimed to assess whether a multicomponent environmental intervention to improve home air quality (PM and secondhand smoke [SHS] exposure) improves respiratory morbidity among current smokers with COPD.

本研究旨在评估一个多组分的环境干预措施，旨在改善家庭空气质量（包括颗粒物（PM）和二手烟（SHS）暴露），是否能改善当前吸烟者中患有慢性阻塞性肺疾病（COPD）的呼吸系统疾病。

Methods

Current smokers with moderate-to-severe COPD were randomized to receive active portable high-efficiency -particulate air cleaners and motivational interviewing (MI) for PM and SHS reduction, respectively; or sham air cleaners -without MI.

患有中度至重度COPD的当前吸烟者被随机分配接受活性便携式高效颗粒空气清洁器和针对PM和SHS减少的动机性访谈（MI）；或者接受无MI的模拟空气清洁器。

The primary outcome was 6-month change in Saint George's Respiratory Questionnaire.

主要结果是6个月圣乔治呼吸问卷的变化。

Secondary outcomes were respiratory symptoms, exacerbation risk, and lung function.

次要结果是呼吸症状、急性加重风险和肺功能。

main_results

Among 121 randomized participants, 99 completed the study.

在121名随机参与者中，有99人完成了研究。

The active intervention resulted in reduced PM levels compared to control, but no reduction in indoor SHS exposure.

主动干预措施导致颗粒物（PM）水平降低，与对照组相比有所改善，但室内二手烟（SHS）暴露量并未减少。

Those in the active arm showed a clinically and statistically significant improvement in total Saint George's Respiratory Questionnaire score compared to control (ß -4.4 [95% confidence interval, -8.2 to -0.5]; P = .025).

主动治疗组在圣乔治呼吸问卷总分上与对照组相比显示出临床上和统计学上的显著改善（ß -4.4 [95% 置信区间, -8.2 至 -0.5]; P = .025）。

Secondary analyses indicated significant improvement in respiratory symptoms (dyspnea and cough) and health status as measured by COPD Assessment Test and clinical COPD questionnaire among the active group (vs. control).

次要分析显示，与对照组相比，主动治疗组在呼吸症状（呼吸困难和咳嗽）和健康状况方面有显著改善，这些是通过慢性阻塞性肺疾病评估测试和临床慢性阻塞性肺疾病问卷来衡量的。

There was no significant difference in forced expiratory volume in 1 second change, sputum symptoms, or odds of exacerbations between groups.

在两组之间，第一秒用力呼气量的变化、痰症状或急性加重的几率没有显著差异。

Conclusions

This study is the first to demonstrate potential health benefits from an environmental intervention in active smokers with COPD, most likely attributable to PM reduction associated with portable high-efficiency particulate air cleaner use.

这项研究首次证明了在活跃吸烟者中患有COPD的个体，通过使用便携式高效颗粒空气清洁器减少PM（颗粒物）相关联的环境干预可能带来的健康益处。