Effect of continuous positive airway pressure on blood pressure in normotensive individuals with obstructive sleep apnoea: a randomised trial.

We assessed the impact of CPAP on BP in normotensive subjects with a dipping BP pattern and severe obstructive sleep apnoea (OSA).

我们评估了CPAP对有血压下降模式和严重阻塞性睡眠呼吸暂停（OSA）的正常血压受试者血压的影响。

Methods

This was a randomised, parallel, prospective, controlled trial. Inclusion criteria were: age ≥18 years, apnoea-hypopnoea index ≥30 events·h-1, mean 24-h BP <130/80 mmHg and daytime to night-time BP reduction ≥10%.

这是一项随机平行前瞻性对照试验。纳入标准为：年龄≥18岁，呼吸暂停低通气指数≥30次·小时-1，24小时平均血压<130/80毫米汞柱，且白天与夜间血压下降≥10%。

Patients were randomly assigned to receive either CPAP treatment or usual care for 12 weeks.

患者被随机分配接受连续气道正压通气（CPAP）治疗或常规护理，持续12周。

The primary outcome was the change in ambulatory BP monitoring (ABPM) parameters from baseline to the 3-month follow-up.

主要结果是步行血压监测（ABPM）参数从基线到3个月随访的变化。

Results

The 60 patients who completed the follow-up had a mean±sd age of 52.2±10.8 years and 40 (66.7%) were male.

完成随访的60名患者平均年龄为52.2±10.8岁，其中40名（66.7%）为男性。

The intention-to-treatanalysis showed no significant changes with CPAP, whereas the usual care group experienced increases in ABPM parameters.

意向治疗分析显示，使用持续气道正压通气（CPAP）治疗无显著变化，而常规护理组的动态血压监测（ABPM）参数有所增加。

This resulted in a mean difference of -3.4 mmHg (95% CI -6.124- -0.676; p=0.015) in night-time diastolic BP between the groups.

这导致两组间夜间舒张压的平均差异为-3.4毫米汞柱（95%置信区间-6.124至-0.676；p=0.015）。

The per-protocol analysis indicated significant differences between the CPAP and usual care groups for all primary end-points, except for daytime systolic BP.

按方案分析显示，除了日间收缩压外，持续气道正压通气（CPAP）组与常规护理组在所有主要终点上存在显著差异。

For night-time systolic BP, the mean difference was -6.052 mmHg (95% CI -10.895- -1.208; p=0.016).

对于夜间收缩压，平均差异为-6.052毫米汞柱（95%置信区间-10.895至-1.208；p=0.016）。

Conclusions

These findings suggest a protective effect of CPAP, highlighting the importance of CPAP prescription for this population to control potential increases in BP and possibly prevent the onset of hypertension.

这些发现表明持续气道正压通气（CPAP）具有保护作用，强调了为这一人群开具CPAP处方的重要性，以控制血压（BP）的潜在升高，并可能预防高血压的发生。