Post-Hospitalisation COVID-19 Rehabilitation (PHOSP-R): a randomised controlled trial of exercise-based rehabilitation.

We aimed to determine the efficacy of exercise-based rehabilitation interventions, either face-to-face or remote, compared to usual care in individuals experiencing post-COVID syndrome following a hospitalisation with acute COVID-19.

我们的目标是确定运动康复干预措施的有效性，无论是面对面还是远程，与常规护理相比，在经历过急性 COVID-19 住院治疗后出现 Post-COVID 综合征的个体中。

Methods

This single-blind randomised controlled trialcompared two exercise-based rehabilitation interventions (face-to-face or remote) to usual care in participants with post-COVID syndrome following a hospitalisation.

这项单盲随机对照试验比较了两种基于运动的康复干预措施（面对面或远程）与常规护理，在经历住院治疗后的COVID后综合症患者中的效果。

The interventions were either a face-to-face or remote 8-week programme of individually prescribed exercise and education.

干预措施包括为期8周的面对面或远程个体化运动和教育计划。

The primary outcome was the change in Incremental Shuttle Walking Test (ISWT) following 8 weeks of intervention (either face-to-face or remote) compared to usual care.

主要结果是干预8周后（面对面或远程）与常规护理相比，增量穿梭步行测试（ISWT）的变化。

Other secondary outcomes were measured including health-related quality of life (HRQoL), and exploratory outcomes included lymphocyte immunotyping.

其他次要结果包括健康相关生活质量（HRQoL）的测量，探索性结果包括淋巴细胞免疫分型。

Results

181 participants (55% male, mean±sd age 59±12 years, length of hospital stay 12±19 days) were randomised.

共有181名参与者（55%为男性，平均年龄59±12岁，住院时间12±19天）被随机分配。

There was an improvement in the ISWT distance following face-to-face rehabilitation (mean 52 m, 95% CI 19-85 m; p=0.002) and remote rehabilitation (mean 34 m, 95% CI 1-66 m; p=0.047) compared to usual care alone.

与仅接受常规护理相比，面对面康复后ISWT距离有所改善（平均52米，95%置信区间19-85米；p=0.002）和远程康复后（平均34米，95%置信区间1-66米；p=0.047）。

There were no differences between groups for HRQoL self-reported symptoms.

两组间在自我报告的症状上没有差异。

Analysis of immune markers revealed significant increases in naïve and memory CD8+ T-cells following face-to-face rehabilitation versus usual care alone (p<0.001, n=31).

对免疫标志物的分析揭示了在面对面康复与常规护理相比，naïve和记忆CD8+ T细胞显著增加（p<0.001，n=31）。

Conclusions

Exercise-based rehabilitation improved short-term exercise capacity in post-COVID syndrome following an acute hospitalisation and showed potential for beneficial immunomodulatory effects.

基于运动的康复治疗在急性住院后的COVID后综合症患者中改善了短期运动能力，并显示出有益的免疫调节效应的潜力。