Optimised oxygenation improves functional capacity during daily activities in patients with COPD on long-term oxygen therapy: a randomised crossover trial.

However, the impact of optimising oxygenation during everyday tasks remains unexplored.

然而，优化日常任务期间的氧合影响尚未被探索。

Therefore, we investigated the effects of maintaining a target saturation on activities of daily living (ADL) using automated oxygen titration compared with conventional fixed oxygen flow.

因此，我们研究了使用自动氧调技术维持目标饱和度对日常生活活动（ADL）的影响，与传统的固定氧流量进行了比较。

Methods

In a double-blinded, randomised crossover trial, patients with COPD on LTOT performed two GlittreADL tests to assess the functional capacity of everyday activities using (1) their fixed oxygen dose and (2) an adjusted flow from 0 to 8 L/min targeting a peripheral oxygen saturation (SpO2) of 90-94%.

在一个双盲、随机交叉试验中，接受长期氧疗（LTOT）的慢性阻塞性肺疾病（COPD）患者进行了两次GlittreADL测试，以评估使用（1）固定氧剂量和（2）从0到8升/分钟调整流量时，针对外周氧饱和度（SpO2）为90-94%的日常活动功能能力。

A closed-loop device automatically titrated the oxygen based on information from a Bluetooth wrist pulse oximeter.

闭环装置根据蓝牙腕式脉搏血氧仪的信息自动调节氧气输送。

Results

31 patients (mean±SD age: 72.8±5.9 years, forced expiratory volume in 1 s of % predicted: 36.7±12.7) were included.

纳入了31名患者（平均年龄±标准差：72.8±5.9岁，第一秒用力呼气容积占预测值百分比：36.7±12.7%）。

The patients reduced the time to perform the ADL test by median (IQR) 38 (12-73) s, p<0.001, using automated titration compared with the fixed oxygen flow.

使用自动调节氧流量的患者与固定氧流量相比，完成日常生活活动(ADL)测试的时间中位数(IQR)减少了38(12-73)秒，p<0.001。

The oxygen flow in the automated arm more than tripled to 5.4 (4.1-6.8) versus 1.6 (1.1-2.1) L/min (fixed) during the test, p<0.001, while the time spent within SpO2-target was increased from 19% to 49%, p=0.002.

在测试期间，自动调节组的氧流量增加超过三倍，达到5.4(4.1-6.8)升/分钟，而固定组为1.6(1.1-2.1)升/分钟，p<0.001。同时，SpO2目标范围内的停留时间从19%增加到49%，p=0.002。

Correspondingly, the patients experienced less dyspnoea (BorgCR10); 5 (3-7) versus 6 (4-8), p<0.001, in favour of the automated oxygen titration.

相应地，患者经历的呼吸困难（BorgCR10）较少；5（3-7）对比6（4-8），p<0.001，有利于自动氧气滴定。

Conclusions

Improving oxygenation and extending the time spent within target saturation reduced dyspnoea and improved functional capacity in ADL in patients with COPD on LTOT.

改善氧合并延长在目标饱和度内的时间，减少了慢性阻塞性肺疾病（COPD）患者在长期氧疗（LTOT）中的呼吸困难，并改善了日常生活活动（ADL）的功能能力。

trial_registration_number

NCT05553847.

NCT05553847。