Short-term effects of home-based pulmonary rehabilitation during outpatient-managed exacerbations of COPD: a randomised controlled trial.

This study explored the short-term effects and self-reported impact of a home-based PR programme for people with outpatient-managed ECOPD.

本研究探讨了针对门诊管理的慢性阻塞性肺疾病急性加重患者进行家庭肺康复计划的短期效果和自我报告的影响。

Methods

We conducted a mixed-methods randomised controlled trialin people with outpatient-managed ECOPD.

我们在门诊管理的慢性阻塞性肺疾病（ECOPD）患者中进行了一项混合方法的随机对照试验。

Participants were randomly assigned to the control (CG, ie, usual care) or experimental (EG, ie, usual care and 3-week home-based PR) group within 48 hours of the diagnosis (baseline).

参与者在诊断后48小时内（基线）被随机分配到对照组（CG，即常规护理）或实验组（EG，即常规护理和3周的家庭为基础的PR）。

Assessments were performed at baseline and after 3 weeks (post).

在基线时和3周后（随访后）进行了评估。

The COPD assessment test (CAT) was the primary outcome.

慢性阻塞性肺疾病评估测试（CAT）是主要的结果指标。

Secondary outcomes included measures of symptoms and functional capacity.

次要结果包括症状和功能能力的测量。

After PR, interviews were conducted.

PR后，进行了访谈。

Analyses were performed using (non-)parametric mixed analysis of variance, deductive thematic analysis and narrative integration through joint displays.

分析采用了（非）参数混合方差分析、演绎主题分析以及通过联合展示进行叙述整合。

Results

Fifty participants with outpatient-managed ECOPD (78% men, 70±11 years, forced expiratory volume in one second 47.4±16.4% pred) were included.

纳入了50名门诊管理的慢性阻塞性肺疾病（ECOPD）患者（78%为男性，平均年龄70±11岁，第一秒用力呼气容积为47.4±16.4%预测值）。

Significant greater improvements in the EG compared with the CG were found for the CAT (EG Δ-12.5±7.2 vs CG Δ-5.9±7.2, p=0.002) and 12 of 13 other secondary outcome measures.

与对照组相比，实验组在CAT评分（实验组Δ-12.5±7.2 vs 对照组Δ-5.9±7.2, p=0.002）以及其他13项次要结果指标中的12项上显示出显著更大的改善。

A positive self-perceived impact of PR was found on symptoms, control of daily life, health, mental status and empowerment.

发现PR对自我感知的影响在症状、日常生活控制、健康状况、心理状态和赋权方面均为正面。

No adverse events were reported.

未报告任何不良事件。

Conclusions

A 3-week home-based PR programme is safe, meaningful and more effective than just standard medication in improving symptoms, functional capacity and health status, outcomes often associated with poor prognosis.

为期3周的家庭肺康复计划在改善症状、功能能力和健康状况方面是安全的、有意义的，并且比单纯的标准药物治疗更有效，这些结果通常与预后不良相关。

This highlights the role of PR in improving the recovery process during outpatient-managed ECOPD and might contribute to a better prognosis in these individuals.

这突显了PR在改善门诊管理的ECOPD恢复过程中的作用，并可能有助于这些个体更好的预后。

trial_registration

NCT03751670.

NCT03751670。