Recent-onset atrial fibrillation: challenges and opportunities.

At its onset, AF is often low burden, and cardiovascular co-morbidities may be absent or at an early stage.

在发病初期，AF通常负担较轻，心血管共病可能不存在或处于早期阶段。

Thus, the management of recent-onset AF has become an issue of growing importance.

因此，新近发作的房颤管理已成为日益重要的问题。

Professional guidelines have traditionally focused on anticoagulant thromboprophylaxis, generally recommending a cautious approach to rhythm control, and priority has been given to rate control to alleviate symptoms.

专业指南传统上侧重于抗凝血预防血栓形成，通常建议对节律控制采取谨慎的方法，并优先考虑控制心率以缓解症状。

In recent guidelines, the importance of managing lifestyle and co-morbidities has increased.

在最近的指南中，管理和生活方式以及共病的重要性有所增加。

The AF-SCREEN collaboration proposes that a vigorous approach to active management of recent-onset AF may be warranted.

AF-SCREEN合作组织提出，对新近发作的房颤采取积极的主动管理方法可能是合理的。

This includes addressing co-morbidities and promoting healthy lifestyles to prevent the emergence or progression of AF and associated cardiovascular disease, as well as the initiation of active rhythm control ± anticoagulation to prevent AF-related morbidity and mortality, including stroke and heart failure (HF).

这包括解决共病问题和促进健康生活方式，以预防房颤（AF）及其相关心血管疾病的出现或进展，以及启动积极的节律控制±抗凝治疗，以预防与AF相关的发病率和死亡率，包括中风和心力衰竭（HF）。

Intuitively, intervention early after AF onset would be beneficial since lifestyle and co-morbidity management, plus rhythm control and anticoagulation, are important contributors to improved outcomes in patients with established AF, but robust evidence is lacking for recent-onset AF.

直观地看，AF发病后早期干预是有益的，因为生活方式和共病管理，加上节律控制和抗凝治疗，是改善已确立AF患者预后的重要因素，但对于新近发生的AF，缺乏强有力的证据。

There is a delicate balance between achieving favourable outcomes such as preventing strokes, HF and AF progression vs the complications and potential adverse effects of interventions.

在预防中风、心力衰竭和房颤进展等有利结果与干预措施的并发症和潜在不良反应之间存在微妙的平衡。

Given the serious long-term consequences, innovative approaches are necessary to determine the value and risks of initiating active therapy very early in the course of AF.

鉴于严重的长期后果，有必要采用创新方法来确定在房颤早期阶段非常早期开始积极治疗的价值和风险。

More data are needed to guide the best management of recent-onset AF, bearing AF burden in mind.

需要更多数据来指导新近发作的房颤的最佳管理，同时考虑到房颤的负担。

Long-term studies using large national databases linked to electronic medical records and rhythm monitoring devices offer excellent opportunities.

使用大型国家数据库与电子病历和节律监测设备链接的长期研究提供了极佳的机会。

Shorter-term studies focusing on reducing AF burden to slow AF progression and studies focusing on outcomes such as HF could be used in both randomized clinical trials and observational cohort studies.

短期研究侧重于减少房颤负荷以减缓房颤进展，以及侧重于心力衰竭等结果的研究，均可用于随机临床试验和观察性队列研究。