Remote ischaemic conditioning improves outcomes of ischaemic stroke treated by endovascular thrombectomy: the SERIC-EVT trial.

This study aimed to assess the efficacy and safety of remote ischaemic conditioning (RIC), a promising neuroprotective treatment, in patients with acute ischaemic stroke who received endovascular thrombectomy.

本研究旨在评估远程缺血条件化（RIC），一种有前景的神经保护治疗，在接受血管内血栓切除术的急性缺血性中风患者中的疗效和安全性。

Methods

This participant-blinded, randomized controlled clinical trial was conducted at 25 hospitals.

这是一项参与者盲法、随机对照的临床试验，研究在25家医院进行。

Patients were randomized 1:1 to either the RIC (cuff pressure, 200 mmHg; twice daily for 7 days) or sham RIC (60 mmHg; same procedure) groups.

患者按1:1的比例随机分配到RIC组（袖带压力200毫米汞柱；每天两次，持续7天）或假性RIC组（60毫米汞柱；相同程序）。

The primary outcome was the proportion of patients with a modified Rankin Scale score of 0-2 on Day 90.

主要结果是在第90天时，改良Rankin量表评分为0-2的患者比例。

The primary safety outcome was the proportion of patients with haemorrhagic transformation within 7 days.

主要安全性结果是在7天内发生出血性转化的患者比例。

Results

In total, 498 participants were recruited.

总共招募了498名参与者。

Ten patients (2.0%) were excluded because they did not receive any intervention.

有10名患者（占2.0%）因未接受任何干预而被排除在外。

Thus, 488 participants (244 in the RIC group and 244 in the sham RIC group) were included in the modified intention-to-treatanalysis.

因此，共有488名参与者（RIC组244人，假RIC组244人）被纳入改良意向治疗分析。

At 90 days, 61.1% of the patients in the RIC group and 48.9% in the sham RIC group achieved a modified Rankin Scale score of 0-2 (unadjusted risk ratio 1.25, 95% confidence interval1.06-1.47; P = .009).

在90天时，RIC组中有61.1%的患者和假RIC组中有48.9%的患者达到了改良Rankin量表评分0-2分（未调整的风险比为1.25，95%置信区间为1.06-1.47；P = .009）。

The proportion of patients with haemorrhagic transformation was 37.7% and 35.2% in the RIC and sham RIC groups, respectively.

在RIC组和假RIC组中，分别有37.7%和35.2%的患者出现了出血性转化。

Conclusions

Among patients with acute ischaemic stroke who underwent endovascular thrombectomy, intervention with RIC for 7 days, compared with sham RIC, resulted in an improved functional outcome at 90 days.

在进行血管内血栓切除术的急性缺血性中风患者中，与假RIC相比，RIC干预7天后，90天的功能结果有所改善。