Type 2 Diabetes Remission: A Systematic Review and Meta-analysis of Nonsurgical Randomized Controlled Trials.

We assessed the effect of nonsurgical randomized controlled trials (RCTs) on type 2 diabetes remission and characterized core components.

我们评估了非手术随机对照试验（RCTs）对2型糖尿病缓解的影响，并对核心组成部分进行了特征描述。

data_sources

We reviewed articles from MEDLINE and Embase (inception to April 2025).

我们回顾了MEDLINE和Embase数据库（从创刊到2025年4月）的文章。

study_selection

RCTs of multimodal pharmacological or nonpharmacological type 2 diabetes remission interventions for adults with type 2 diabetes were included.

纳入了针对成年2型糖尿病患者的多模式药物或非药物2型糖尿病缓解干预的随机对照试验(RCTs)。

data_extraction

Study characteristics and outcomes for clinical/population health, patient-reported, and adverse eventwere extracted.

提取了临床/人群健康、患者报告和不良事件的研究特征和结果。

data_synthesis

We performed a random-effects multilevel meta-analysisof studies, grouped based on type of intervention and by length of follow-up.

我们根据干预类型和随访时间长度对研究进行了随机效应多水平荟萃分析。

A total of 18 studies were included in this review from 11 different countries.

本综述共纳入了来自11个不同国家的18项研究。

There was a higher likelihood of achieving type 2 diabetes remission through multimodal interventions (risk ratio [RR] 1.75 [95% CI 1.49-2.04]) and for nonpharmacological interventions (RR 5.80 [95% CI 4.28-7.87]), compared with the control group.

与对照组相比，通过多模式干预（风险比[RR] 1.75 [95% 置信区间 1.49-2.04]）和非药物干预（RR 5.80 [95% 置信区间 4.28-7.87]）实现2型糖尿病缓解的可能性更高。

Other significant outcomes for intervention groups compared with control groups included change in A1C, weight loss, and quality of life and improvements in adverse events of hypoglycemia.

干预组与对照组相比的其他显著结果包括A1C的变化、体重减轻以及生活质量的改善，以及低血糖不良事件的改善。

limitations

There was heterogeneity in our small pool of included studies (diversity of nonpharmacological components), stringent intervention protocols, narrow participant selection criteria, and lack of consistent diabetes remission definitions.

我们纳入的研究样本量较小，存在异质性（非药物成分的多样性）、严格的干预方案、狭窄的参与者选择标准以及缺乏一致的糖尿病缓解定义。

Conclusions

With specific protocols, a variety of tailored approaches can induce type 2 diabetes remission for patients with newly diagnosed type 2 diabetes who are able to subscribe to strict protocols.

通过特定方案，一系列量身定制的方法可以诱导新诊断的2型糖尿病患者在能够遵守严格方案的情况下实现2型糖尿病的缓解。

Consideration of long-term sustainability and effectiveness is needed in future research, along with patient preferences.

未来的研究需要考虑长期的可持续性和有效性，同时也要考虑患者的偏好。