Thyroid-joint crosstalk: a systematic review and meta-analysis of thyroid autoimmunity and dysfunction in juvenile idiopathic arthritis.

Despite the growing evidence of thyroid involvement in JIA, available data are heterogeneous and fragmented.

尽管有关甲状腺在JIA中涉及的证据越来越多，但现有数据是异质的和零散的。

We aimed to systematically review the available evidence on the prevalenceof thyroid autoantibody positivity and thyroid dysfunction in patients with JIA.

我们的目标是系统地审查关于JIA患者甲状腺自身抗体阳性率和甲状腺功能障碍的可用证据。

Methods

PubMed/Medline, Cochrane, and Scopus databases were approached to identify studies reporting data on thyroid autoantibody positivity and dysfunction in children with JIA.

我们接触了PubMed/Medline、Cochrane和Scopus数据库，以确定报告有关JIA儿童甲状腺自身抗体阳性率和功能障碍数据的研究。

Results

A total of 15 studies were included in the final analysis, encompassing 19 015 children with JIA (13 225 females, 69.6%) with a weighted mean age of 8.0 years (range 1.8-21 years).

最终分析包括了15项研究，涵盖了19 015名JIA儿童（13 225名女性，占69.6%），加权平均年龄为8.0岁（范围1.8-21岁）。

The pooled prevalenceestimates of antithyroid antibody positivity and thyroid dysfunction were 0.04 (95% CI: 0.03-0.05) and 0.04 (95% CI: 0.03-0.08), respectively.

甲状腺自身抗体阳性和甲状腺功能障碍的汇总患病率估计分别为0.04（95%置信区间：0.03-0.05）和0.04（95%置信区间：0.03-0.08）。

The risk difference for thyroid autoantibody positivity between children with JIA and controls was 0.08 (95% CI: 0.02-0.14).

JIA儿童与对照组之间的甲状腺自身抗体阳性风险差异为0.08（95%置信区间：0.02-0.14）。

Possible risk factors were analyzed: the presence of family history for thyroid autoimmune disease (odds ratio - OR 3.91, 95% CI 1.86-8.25), concurrent Antinuclear Antibodies (ANA) positivity (OR 1.62, 95% CI 1.13-2.31), and older age (MD 2.10 years, 95% CI 1.32-2.89) were associated with thyroid autoantibody positivity and/or thyroid dysfunction in children with JIA.

分析了可能的风险因素：甲状腺自身免疫疾病家族史的存在（比值比-OR 3.91，95%置信区间1.86-8.25）、同时抗核抗体（ANA）阳性（OR 1.62，95%置信区间1.13-2.31）和年龄较大（平均差2.10岁，95%置信区间1.32-2.89）与JIA儿童的甲状腺自身抗体阳性及/或甲状腺功能障碍相关。

No significant difference emerged for the specific JIA form.

特定的JIA形式没有出现显著差异。

Conclusions

Thyroid dysfunction may be detected in children with JIA, with a significant risk difference in comparison to healthy controls.

患有JIA的儿童中可能会检测到甲状腺功能障碍，与健康对照组相比存在显著的风险差异。

Specific clinical characteristics, such as family history, ANA positivity, and older age at JIA onset, may suggest which patients should benefit from thyroid autoantibody screening.

特定的临床特征，如家族史、ANA阳性以及JIA发病时年龄较大，可能表明哪些患者应该从甲状腺自身抗体筛查中受益。