Home-based, remotely supervised, high-intensity interval training and cardiorespiratory fitness in children and adolescents with post-infectious bronchiolitis obliterans: a randomised controlled trial.

Our aim was to assess the effects of a home-based, remotely supervised, HIIT programme on CRF, clinical and functional variables in patients with PIBO.

我们的目标是评估家庭基础、远程监督的HIIT计划对PIBO患者的心肺功能、临床和功能变量的影响。

Methods

Participants of this assessor-blinded, multicentre, randomised controlled trialwere individuals with PIBO aged 6-20 years.

这项评估者盲法、多中心、随机对照试验的参与者是年龄在6-20岁之间的PIBO患者。

An exercise (EXE) group underwent two 40-min sessions of HIIT remotely supervised in real time per week.

一个运动（EXE）组每周进行两次40分钟的HIIT，通过远程实时监督。

Sessions were continued for 16 weeks.

这些课程持续了16周。

The control (CON) group adhered to general physical activity recommendations.

对照（CON）组遵循一般的体力活动建议。

The primary outcome was peak oxygen uptake (V̇ O2 peak), time to first ventilatory threshold (VT1), percentage of V̇ O2 at VT1 and ventilatory equivalent for carbon dioxide, determined via cardiopulmonary exercise testing on a treadmill.

主要结果是峰值氧气摄取量（V̇ O2 peak）、达到首次通气阈值（VT1）的时间、VT1时的氧气摄取量百分比以及二氧化碳的通气当量，通过跑步机上的心肺运动测试确定。

Secondary outcomes were lung function (spirometry), muscle strength (dynamometry), functional capacity (30-s sit-to-stand (30s-STS) test), body mass index and St George's Respiratory Questionnaire score.

次要结果是肺功能（肺活量计）、肌肉力量（测力计）、功能能力（30秒坐立测试（30s-STS））、体重指数和圣乔治呼吸问卷评分。

Results

51 PIBO patients were enrolled (EXE group n=25; CON group n=26) (49% females; mean±sd age 13.3±4.2 years; forced expiratory volume in 1 s -3.56±1.28 (z-score); V̇ O2 peak 36.8±8.6 mL·kg-1·min-1).

共有51名PIBO患者参与研究（EXE组n=25；CON组n=26）（女性占49%；平均年龄13.3±4.2岁；1秒钟用力呼气容积-3.56±1.28（z分数）；峰值氧耗量36.8±8.6 mL·kg-1·min-1）。

The HIIT intervention resulted in improvements in V̇ O2 peak (mean difference 3.39 mL·kg-1·min-1; p=0.04), time to VT1 (mean difference 1.05 min; p=0.04) and number of repetitions in the 30s-STS test (mean difference 2.21 repetitions; p=0.04).

高强度间歇训练（HIIT）干预导致峰值氧耗量（平均差异3.39 mL·kg-1·min-1；p=0.04）、VT1时间（平均差异1.05分钟；p=0.04）和30秒-STS测试中的重复次数（平均差异2.21次；p=0.04）的改善。

No differences were found in the other variables.

在其他变量中未发现差异。

Conclusions

Our real-time, remotely supervised HIIT intervention was effective at significantly increasing CRF and functional capacity in children and adolescents with PIBO.

我们的实时、远程监督的高强度间歇训练（HIIT）干预在显著提高患有PIBO的儿童和青少年的体能和功能能力方面是有效的。