Occupational Exposure to Asbestos-Free Talc and Risk of Respiratory Cancers, Including Larynx, Lung, and Mesothelioma: A Systematic Review and Meta-Analysis.

However, the findings remain inconclusive.

然而，研究结果尚不明确。

To clarify this, we conducted a systematic reviewand meta-analysisof studies evaluating the incidenceand mortality of lung, mesothelioma, and laryngeal cancers among workers exposed to asbestos-free talc.

为了阐明这一点，我们对评估接触无石棉滑石粉工人中肺癌、间皮瘤和喉癌发生率和死亡率的研究进行了系统评价和荟萃分析。

Methods

We searched MEDLINE (PubMed) and SCOPUS databases up to January 2026 for cohort and case-control studies.

我们搜索了MEDLINE（PubMed）和SCOPUS数据库，直到2026年1月，以寻找队列研究和病例对照研究。

Study quality was assessed using a modified Newcastle-Ottawa Scale.

研究质量使用改良的新堡-渥太华量表进行评估。

Meta-analyses were conducted for lung using a random-effects model and crude model for laryngeal cancer, whereas mesothelioma findings were synthesized through a systematic review.

对于肺癌，使用随机效应模型进行荟萃分析，对于喉癌，使用未调整模型进行荟萃分析，而间皮瘤的结果则是通过系统综述合成的。

Publication bias was evaluated using funnel plots and Egger's test.

使用漏斗图和Egger检验评估了发表偏倚。

Results

We identified 13, eight, and seven publications reporting on lung cancer, mesothelioma, and laryngeal cancer, respectively.

我们分别确定了13篇、8篇和7篇分别报道肺癌、间皮瘤和喉癌的出版物。

Five studies on lung cancer in talc miners and millers and three studies in other industries were included in the meta-analysis.

本荟萃分析纳入了五项关于滑石矿工和磨工肺癌的研究，以及三项其他行业的研究。

The pooled relative risk of lung cancer was 1.13 (95% confidence interval[CI]: 0.97-1.33) for miners and millers and 1.12 (95% CI: 0.79-1.57) for other workers.

肺癌的汇总相对风险为矿工和磨工1.13（95%置信区间[CI]: 0.97-1.33），其他工人1.12（95% CI: 0.79-1.57）。

No publication bias was found (p = 0.45).

未发现发表偏倚（p = 0.45）。

No mesothelioma cases were reported among talc miners and millers, precluding meta-analysis.

在滑石矿工和磨工中未报告间皮瘤病例，这使得无法进行荟萃分析。

Studies on laryngeal cancer revealed no association with talc exposure (relative risk = 0.98, 95% CI: 0.58-1.57).

关于喉癌的研究显示，与滑石粉暴露无关联（相对风险=0.98，95%置信区间：0.58-1.57）。

Conclusions

Current evidence does not support increased risks of lung, mesothelioma, or laryngeal cancers among workers exposed to asbestos-free talc.

当前的证据并不支持在接触无石棉滑石粉的工人中，肺癌、间皮瘤或喉癌风险增加。

Future studies should better control for confounders, especially tobacco smoking.

未来的研究应更好地控制混杂因素，特别是烟草吸烟。