A Game-Changing 20 Years: Progress and Future Directions in Lung Cancer Screening.

Landmark trials, including NLST and NELSON, demonstrated mortality reductions exceeding 20%, establishing LDCT as the standard of care for early detection in high-risk populations.

包括NLST和NELSON在内的里程碑式试验显示，死亡率降低了超过20%，确立了LDCT作为高风险人群早期检测的标准护理。

Currently, 13 countries have implemented national or regional LCS programs, with additional nations preparing for rollout.

目前，已有13个国家实施了全国或区域性肺癌筛查（LCS）计划，还有更多国家正在准备推广。

Advances in risk-prediction models, volumetric nodule assessment, and structured management protocols have improved precision and efficiency.

在风险预测模型、体积结节评估和结构化管理协议方面的进步，提高了精确度和效率。

Integration of artificial intelligence is enhancing nodule detection, prediction of malignancy risk, individualized screening intervals, and workflow optimization.

人工智能的整合正在提高结节检测、恶性风险预测、个性化筛查间隔以及工作流程优化。

Real-world evidence confirms improved stage distribution and suggests reduction in lung cancer mortality.

真实世界证据证实了肺癌分期分布的改善，并暗示肺癌死亡率有所降低。

Initiatives such as promoting community engagement, equitable access through geospatial mapping, and mobile screening will improve screening uptake and retention.

通过促进社区参与、利用地理空间映射实现公平获取资源以及移动筛查等举措，将提高筛查的接受度和留存率。

Embedding tobacco dependence treatment within LCS further augments life-years gained.

将烟草依赖治疗嵌入到肺癌筛查（LCS）中，将进一步增加获得的寿命年。

Complementary incidental pulmonary-nodule programs and expanding studies in people who have never smoked are extending the reach of early detection, whereas biomarker research is progressing toward integration with imaging-based screening.

补充的偶然性肺结节计划和在从未吸烟人群中扩展的研究正在扩大早期检测的范围，而生物标志物研究正在向与基于影像的筛查相结合的方向发展。

The potential to use LDCT scans to detect coronary heart disease and chronic obstructive pulmonary disease may have a major impact on future health care benefits.

使用低剂量计算机断层扫描(LDCT)检测冠状动脉心脏病和慢性阻塞性肺病的潜力可能会对未来医疗保健福利产生重大影响。

Ongoing efforts to harmonize data collection standards, establish quality indicators, and strengthen workforce training are essential to sustain high-quality implementation.

持续努力统一数据收集标准、建立质量指标和加强工作人员培训对于维持高质量实施至关重要。

As LCS evolves into a cornerstone of lung cancer control, continued innovation in risk stratification, imaging technologies, and biomarker integration will be key to maximizing global benefit and equity.

随着肺癌筛查（LCS）成为肺癌控制的基石，风险分层、影像技术和生物标志物整合的持续创新将是最大化全球利益和公平的关键。