Low-plastic diet and urinary levels of plastic-associated phthalates and bisphenols: the randomized controlled PERTH Trial.

We present the results of the Plastic Exposure Reduction Transforms Health Trial, with an observational cohort of 211 Australian participants and a 7-day pilot randomized controlled trialin 60 participants.

我们展示了减少塑料暴露转化健康试验的结果，该试验包括211名澳大利亚参与者的一个观察性队列和60名参与者的为期7天的试点随机对照试验。

Intervention groups received combinations of plastic-free kitchenware, low-plastic personal-care products and food sourced from more than 100 producers that minimized all plastic touchpoints from paddock to plate, while the control group received no intervention.

干预组接受了无塑料厨房用具、低塑料个人护理产品以及来自超过100个生产者的食品组合，这些食品从生产到餐桌最小化了所有塑料接触点，而对照组没有接受任何干预。

The primary trial outcome was a reduction in urinary plastics-associated chemicals levels.

主要试验结果是尿液中与塑料相关的化学物质水平的降低。

In the cohort study, highly processed, plastic-packaged and canned foods were important modifiable factors for urinary PAC metabolite levels.

在队列研究中，高度加工的塑料包装和罐装食品是尿液PAC代谢产物水平的重要可修改因素。

Additionally, we observed negative associations between cardiometabolic biomarkers and higher urinary di(2-ethylhexyl) phthalate metabolites.

此外，我们观察到心血管代谢生物标志物与较高尿液二（2-乙基己基）邻苯二甲酸酯代谢产物之间存在负相关性。

Our randomized controlled dietary intervention maintained participants' daily energy intake while decreasing plastic exposure (P < 0.001) and urinary levels of mono-n-butyl phthalate, monobenzyl phthalate and bisphenol A by 37.5% (95% confidence interval(CI): -55.6, -12.0; P = 0.007), 53.5% (95% CI: -72.7, -20.6; P = 0.005) and 59.7% (95% CI: -82.5, -6.87; P = 0.033), respectively.

我们的随机对照饮食干预在维持参与者的每日能量摄入的同时，减少了塑料暴露（P < 0.001），并使尿液中的单正丁基邻苯二甲酸酯、单苄基邻苯二甲酸酯和双酚A水平分别降低了37.5%（95%置信区间（CI）：-55.6, -12.0; P = 0.007）、53.5%（95% CI: -72.7, -20.6; P = 0.005）和59.7%（95% CI: -82.5, -6.87; P = 0.033）。

Intervention groups provided with foods that had minimal to no contact with plastic had the broadest effect on PAC excretion, and replacing low-plastic personal-care products alone led to an independent decrease in urinary mono-n-butyl phthalate, compared to no intervention.

提供给干预组的食品几乎没有或根本没有与塑料接触，对PAC排泄的影响最为广泛，仅替换低塑料个人护理产品就导致尿液中单正丁基邻苯二甲酸酯的独立降低，与无干预相比。

Despite constant plastic exposures, limiting food plastics touchpoints decreases select PACs in 7 days.

尽管持续接触塑料，减少食物与塑料的接触点在7天内降低了特定的多环芳烃化合物（PACs）水平。

Australian and New Zealand Clinical Trials Registry: ACTRN12622001252707 .

澳大利亚和新西兰临床试验注册处：ACTRN12622001252707。