Effects of daily multivitamin-multimineral and cocoa extract supplementation on epigenetic aging clocks in the COSMOS randomized clinical trial.

This prespecified ancillary study evaluated the 2-year effect of a daily MVM (Centrum Silver) and cocoa extract (500 mg cocoa flavanols per day, including 80 mg (-)-epicatechin) on five DNA methylation measures of biological aging (PCHannum, PCHorvath, PCPhenoAge, PCGrimAge and DunedinPACE) among 958 participants (482 women and 476 men) in the COcoa Supplement and Multivitamin Outcomes Study (COSMOS).

这项预先指定的辅助研究评估了每日服用MVM（Centrum Silver）和可可提取物（每天500毫克可可黄烷醇，包括80毫克(-)-表儿茶素）对958名参与者（482名女性和476名男性）在可可补充剂和多维生素结果研究（COSMOS）中对五种DNA甲基化生物衰老指标（PCHannum, PCHorvath, PCPhenoAge, PCGrimAge和DunedinPACE）的2年影响。

Compared with placebo, daily MVM supplementation modestly reduced the rate of increase of second-generation epigenetic clocks, with a between-group difference in yearly change of -0.113 years (95% confidence interval(CI) -0.205 to -0.020; P = 0.017) for PCGrimAge and -0.214 years (-0.410 to -0.019; P = 0.032) for PCPhenoAge.

与安慰剂相比，每日补充MVM（多种维生素矿物质）轻微降低了第二代表观遗传时钟的增长速率，PCGrimAge的组间差异为每年-0.113年（95%置信区间（CI）-0.205至-0.020；P=0.017），PCPhenoAge的组间差异为-0.214年（-0.410至-0.019；P=0.032）。

MVM had a stronger effect on PCGrimAge among those with accelerated biological aging at baseline (-0.236 [-0.380 to -0.091]) compared with those with normal or decelerated biological aging (-0.013 [-0.130 to 0.104]; P = 0.018 for interaction).

在基线时生物年龄加速的个体中，MVM对PCGrimAge的影响更强（-0.236 [-0.380至-0.091]），与那些生物年龄正常或减缓的个体（-0.013 [-0.130至0.104]；P=0.018 for interaction）相比。

Cocoa extract did not have an effect on the five epigenetic clocks tested.

可可提取物对所测试的五种表观遗传时钟没有影响。

Although the statistically significant but small effects of daily MVM supplementation on slowing biological aging are encouraging, additional studies are needed to determine the clinical relevance of daily MVM supplementation on epigenetic clocks and whether such effects can help explain the beneficial effects of MVM supplementation on aging-related chronic conditions.

尽管每日多维生素矿物质(MVM)补充对延缓生物衰老的统计学上显著但小幅度的效果令人鼓舞，但需要额外的研究来确定每日MVM补充对表观遗传时钟的临床相关性，以及这些效果是否能帮助解释MVM补充对与衰老相关的慢性疾病有益效果的原因。