Head-to-head comparison of MASH resolution index versus FAST for noninvasive prediction of resolution of MASH on biopsy.

This study aimed to examine head-to-head the diagnostic accuracy of the MASHResInd versus FAST score in detecting MASH resolution.

本研究旨在直接比较MASH分辨率指数（MASHResInd）与FAST评分在检测MASH消解方面的诊断准确性。

approach_and_results

This prospective study included 160 participants (64% female) with biopsy-proven MASH and stage 2 or stage 3 fibrosis from a randomized, multicenter trial of pegozafermin.

这项前瞻性研究包括了160名参与者（64%为女性），这些参与者均通过活检证实患有MASH，并且处于2期或3期纤维化阶段，他们来自一项关于pegozafermin的随机、多中心试验。

Participants received either pegozafermin or placebo and underwent contemporaneous liver biopsies, magnetic resonance imaging-proton density fat fraction, and vibration-controlled transient elastography at 2-time points spaced 24 weeks apart.

参与者接受了pegozafermin或安慰剂治疗，并在相隔24周的两个时间点进行了同时期的肝活检、磁共振成像-质子密度脂肪分数测量和振动控制瞬时弹性成像。

The primary objective was the detection of MASH resolution with no worsening of fibrosis.

主要目标是检测MASH消退且纤维化无恶化的情况。

Diagnostic models were assessed by the area under the receiver operating characteristic curves (AUC) and compared with the Delong test.

诊断模型通过接收者操作特征曲线下的面积（AUC）进行评估，并与Delong检验进行比较。

The median (IQR) age and body mass index of participants were 56.0 (49.0-62.0) years and 36.5 (32.2-40.4) kg/m 2 , respectively.

参与者的中位年龄和体质指数分别为56.0（49.0-62.0）岁和36.5（32.2-40.4）kg/m2。

The MASHResInd outperformed FAST for identifying MASH resolution without worsening fibrosis (AUC: 0.83, 95% CI: 0.75-0.91 vs. 0.65, 95% CI: 0.55-0.75, p =0.001).

在识别MASH（肝微脂肪变性）解决而不加重纤维化方面，MASHResInd的性能优于FAST（AUC: 0.83, 95% 置信区间: 0.75-0.91 vs. 0.65, 95% 置信区间: 0.55-0.75, p =0.001）。

The positive predictive values for MASH resolution were 29% and 26% for the MASHResInd and FAST using rule-in criteria, respectively.

使用纳入标准时，MASH分辨率的阳性预测值分别为MASHResInd的29%和FAST的26%。

The negative predictive values were 100% and 94% for the MASHResInd and FAST using rule-out criteria, respectively.

使用排除标准时，MASH分辨率的阴性预测值分别为MASHResInd的100%和FAST的94%。

Conclusions

The MASHResInd is better than the FAST score in the noninvasive prediction of MASH resolution.

MASHResInd在非侵入性预测MASH消退方面优于FAST评分。

These data may have implications for clinical practice and trials.

这些数据可能对临床实践和试验具有重要意义。