Effects of Supervised Exercise during Neoadjuvant Chemotherapy on Tumor Response in Patients with Breast Cancer (Neo-train): A Randomized Controlled Trial.

However, clinical trials are needed to investigate these findings.

然而，需要进行临床试验来研究这些发现。

We hypothesized that an exercise program during neoadjuvant chemotherapy would improve tumor response in patients with breast cancer.

我们假设在新辅助化疗期间进行的运动计划会改善乳腺癌患者的肿瘤反应。

patients_and_methods

Neo-train was a randomized controlled trialallocating patients with breast cancer to the usual care control (CON) group or the exercise (EX) group that received supervised high-intensity interval training and progressive resistance training 3 times weekly during 18 to 24 weeks of neoadjuvant chemotherapy.

Neo-train 是一项随机对照试验，将乳腺癌患者分配到常规护理对照（CON）组或运动（EX）组，后者在新辅助化疗的18至24周期间每周进行三次监督下的高强度间歇训练和渐进性抗阻训练。

The two groups were compared on tumor size, assessed using magnetic resonance imaging as primary outcome, and secondary clinical/pathologic, biological, physical, and patient-reported outcomes.

两组在肿瘤大小上进行了比较，主要结果使用磁共振成像评估，次要的临床/病理、生物学、物理和患者报告的结果也进行了比较。

Results

From 2021 to 2023, 102 participants were randomly assigned to the EX (n = 50) or CON (n = 52) group.

从2021年到2023年，共有102名参与者被随机分配到EX组（n = 50）或CON组（n = 52）。

We found no between-group differences in median tumor size change from baseline to presurgery (EX vs. CON -3.0 mm [95% confidence interval(CI), -8.0 to 14.0]), the proportion with radiologic complete response [EX 65% vs. CON 56%; odds ratio 1.16 (95% CI, 0.39-3.91)], or pathologic complete response [EX 59% vs. CON 56%; odds ratio 1.03 (95% CI, 0.43-2.46)].

我们发现从基线到术前肿瘤大小中位数变化在实验组和对照组之间没有差异（实验组与对照组 -3.0 毫米 [95% 置信区间 (CI), -8.0 到 14.0]），影像学完全缓解的比例（实验组 65% 对照组 56%；比值比 1.16 [95% CI, 0.39-3.91]），或病理完全缓解的比例（实验组 59% 对照组 56%；比值比 1.03 [95% CI, 0.43-2.46]）。

The exercise program was associated with higher relative dose intensity, fewer dose delays, shorter hospital stays, and increased cardiorespiratory fitness, muscle strength, and level of physical activity.

该运动计划与更高的相对剂量强度、较少的剂量延迟、更短的住院时间以及增加的心肺适能、肌肉力量和身体活动水平相关。

We found no differences in tumor-infiltrating lymphocytes, body composition, health-related quality of life, anxiety, depression, psychological distress, or participation in rehabilitation between groups.

我们在肿瘤浸润淋巴细胞、身体组成、健康相关生活质量、焦虑、抑郁、心理困扰或康复参与方面未发现两组之间存在差异。

Conclusions

Although the exercise program did not affect tumor size, the positive effects on chemotherapy completion and shorter hospitalizations suggest improved treatment tolerance.

尽管运动计划未对肿瘤大小产生影响，但其对化疗完成率的正面效果以及缩短住院时间表明治疗耐受性有所提升。