Transrectal Ultrasound-Guided Prostate Biopsy with and without PSMA-PET-Targeted Prostate Biopsy for Prostate Cancer Diagnosis.

The primary outcome of the study was the accuracy of the two methods in identifying clinically significant prostate cancer (csPCa).

该研究的主要结果是两种方法在识别临床显著性前列腺癌（csPCa）方面的准确性。

The secondary outcomes included accuracy in identifying clinically insignificant prostate cancer (GG1) and GG3 or greater tumors, cancer detection stratified by the previous biopsy status, and the detection rate of csPCa using the combination of PSMA-TB and TRUS-GB.

次要结果包括识别临床上无意义的前列腺癌（GG1）和GG3或更高级别肿瘤的准确性，根据先前活检状态分层的癌症检测率，以及使用PSMA-TB和TRUS-GB组合检测csPCa的检出率。

patients_and_methods

In this multicenter, two-arm, randomized study, biopsy-naïve patients suspected of having prostate cancer and advised to undergo prostate biopsy were randomly assigned to the PSMA-TB + TRUS-GB (combined) and TRUS-GB (control) groups.

在这项多中心、两臂、随机研究中，被怀疑患有前列腺癌并建议进行前列腺活检的活检初学者被随机分配到PSMA-TB + TRUS-GB（联合）组和TRUS-GB（对照）组。

Results

A total of 815 men were assessed for eligibility, and 727 men were randomly assigned to the PSMA-TB + TRUS-GB group or the TRUS-GB group.

共有815名男性被评估以确定资格，其中727名男性被随机分配到PSMA-TB + TRUS-GB组或TRUS-GB组。

The detection rate of csPCa in the group subjected to the combination of PSMA-TB and TRUS-GB was significantly greater than that in the conventional TRUS-GB group (67.0% vs. 60.1%; P = 0.042).

接受PSMA-TB和TRUS-GB联合检测的组中，临床显著性前列腺癌（csPCa）的检出率显著高于传统TRUS-GB组（67.0%对比60.1%；P = 0.042）。

In the PSMA-TB + TRUS-GB group, the rate of csPCa detection by PSMA-TB was significantly greater than that by TRUS-GB (63.5% vs. 57.7%; P < 0.001), whereas the combined strategies achieved the highest detection rate (67.0% vs. 63.5%, P < 0.001; 67.0% vs. 57.7%, P < 0.001).

在PSMA-TB + TRUS-GB组中，通过PSMA-TB检测到的csPCa（临床显著性前列腺癌）的检出率显著高于通过TRUS-GB的检出率（63.5%对比57.7%；P<0.001），而联合策略的检出率最高（67.0%对比63.5%，P<0.001；67.0%对比57.7%，P<0.001）。

Conclusions

The diagnostic efficacy of TRUS-GB with PSMA-TB was significantly greater than that of TRUS-GB alone.

结合PSMA-TB的TRUS-GB诊断效能显著高于单独使用TRUS-GB的诊断效能。

If available, PSMA-TB should be performed alongside TRUS-GB in a combined manner rather than each method alone for the most accurate pathologic results.

如果可行，应将PSMA-TB与TRUS-GB联合使用，而不是单独使用每种方法，以获得最准确的病理结果。