The Efficacy of Texture and Color Enhancement Imaging Observation in the Detection of Colorectal Lesions: A Multicenter, Randomized Controlled Trial (deTXIon Study).

This study aimed to confirm the superiority of texture and color enhancement imaging (TXI) over white light imaging (WLI) in detecting colorectal lesions.

本研究旨在确认纹理和颜色增强成像（TXI）在检测结直肠病变方面相对于白光成像（WLI）的优越性。

Methods

This randomized controlled trialwas conducted at 8 Japanese institutions between March 2023 and October 2023.

这项随机对照试验在日本的8个机构进行，时间从2023年3月到2023年10月。

Participants aged 40 to 80 years old scheduled for CRC screening and nonscreening purposes, such as postpolypectomy surveillance, positive fecal occult blood test results, and abdominal symptoms, were included.

纳入了年龄在40至80岁之间计划进行结直肠癌筛查和非筛查目的的参与者，包括息肉切除术后监测、粪便潜血试验结果阳性以及腹部症状等情况。

We used only the latest model colonoscopes and performed observations in each arm of the TXI mode 1 and WLI.

我们仅使用了最新的结肠镜模型，并在TXI模式1和WLI的每个分支中进行了观察。

The primary end point was the mean number of adenomas detected per procedure.

主要终点是每项程序中检测到的腺瘤平均数量。

Secondary end points included the adenoma detection rate, polyp detection rate, flat polyp detection rate, and adverse events.

次要终点包括腺瘤检出率、息肉检出率、平坦型息肉检出率以及不良事件。

Results

A total of 956 patients were enrolled and randomized.

共有956名患者被纳入并进行了随机分组。

After patients who did not meet the eligibility criteria were excluded, 451 and 445 patients were included in the TXI and WLI arms, respectively.

在排除不符合资格标准的患者后，分别有451名和445名患者被纳入TXI和WLI组。

The mean number of adenomas detected per procedure was 1.4 and 1.5 and the adenoma detection rate was 57.2% and 56.0% in TXI and WLI, respectively, and there were no statistically significant differences between 2 arms.

每项操作中检测到的腺瘤平均数分别为1.4和1.5，腺瘤检测率分别为57.2%和56.0%，两组之间没有统计学显著差异。

The polyp detection rate and flat polyp detection rate were significantly higher in TXI than in WLI, which were 82.5% vs 74.4% (P = .003), and 76.5% vs 70.3% (P = .036), respectively.

TXI的息肉检出率和扁平息肉检出率显著高于WLI，分别为82.5%对74.4%（P = .003）和76.5%对70.3%（P = .036）。

Conclusions

This study did not demonstrate the superiority of TXI over WLI in detecting neoplastic lesions.

本研究未证明TXI在检测肿瘤性病变方面优于WLI。

However, TXI may be effective in detecting flat polyps.

然而，TXI在检测平坦型息肉方面可能是有效的。

(Clinical trial registration: jRCT1032230089.).

（临床试验注册：jRCT1032230089。）