Electroacupuncture Reduces Duration of Postoperative Ileus After Laparoscopic Gastrectomy for Gastric Cancer: A Multicenter Randomized Trial.

We investigated the efficacy of EA in reducing POI duration and enhancing gastrointestinal (GI) recovery in patients undergoing laparoscopic surgery for gastric cancer.

我们研究了电针在减少胃癌患者腹腔镜手术后肠梗阻持续时间以及促进胃肠道（GI）恢复方面的疗效。

Methods

This multicenter randomized trial was conducted at 7 hospitals in China, enrolling 585 participants who underwent laparoscopic resection for gastric cancer from October 27, 2021, to December 21, 2023.

这项多中心随机试验在中国的7家医院进行，招募了585名于2021年10月27日至2023年12月21日期间接受胃癌腹腔镜切除术的参与者。

Participants received perioperative standard care and were randomized to 4 sessions of EA, 4 sessions of sham EA (SA), or standard care only.

参与者接受了围手术期的标准护理，并被随机分配接受4次电针治疗(EA)、4次假电针治疗(SA)或仅接受标准护理。

The primary outcome was the time to first flatus.

主要结果是首次排气的时间。

Secondary outcomes included time to first defecation, dietary recovery, quality of life, postoperative mobilization, and duration of hospital stay.

次要结果包括首次排便时间、饮食恢复、生活质量、术后活动能力和住院时间。

Results

A total of 578 participants were in the full analysis set.

共有578名参与者纳入了完整分析集。

EA exhibited a shorter time to first flatus compared with both SA and standard care, with differences of -12.96 hours (95% confidence interval(CI), -19.17 to -6.75; P < .001) and -24.46 hours (95% CI, -30.61 to -18.30; P < .001), respectively.

EA组相较于SA组和标准护理组，首次排气时间更短，差异分别为-12.96小时（95%置信区间（CI），-19.17至-6.75；P<.001）和-24.46小时（95% CI，-30.61至-18.30；P<.001）。

Similarly, EA significantly reduced the time to first defecation: -15.41 hours (95% CI, -27.73 to -3.09; P = .007) vs SA; -24.66 hours (95% CI, -36.76 to -12.55; P < .001) vs standard care.

同样，EA显著缩短了首次排便时间：-15.41小时（95%置信区间，-27.73至-3.09；P = .007）与SA相比；-24.66小时（95%置信区间，-36.76至-12.55；P < .001）与标准护理相比。

Incidenceof prolonged POI was significantly lower in the EA group than in the SA and standard care groups, with group differences of -0.41 (95% CI, -0.66 to -0.16; P < .001) and -0.56 (95% CI, -0.82 to -0.31; P < .001), respectively.

EA组的延长性术后肠梗阻发生率显著低于SA组和标准护理组，组间差异分别为-0.41（95%置信区间，-0.66至-0.16；P < .001）和-0.56（95%置信区间，-0.82至-0.31；P < .001）。

No severe adverse events were reported.

未报告严重不良事件。

Conclusions

EA was superior to SA and standard care only for reducing POI duration and the risk of prolonged POI in patients undergoing laparoscopic gastrectomy for gastric cancer (Chinese Clinical Trials Register identifier: ChiCTR2100050660).

在胃癌患者接受腹腔镜胃切除术的背景下，EA在减少术后肠梗阻（POI）持续时间和降低POI延长风险方面优于SA和标准护理（中国临床试验注册号：ChiCTR2100050660）。