Supportive care interventions in hematopoietic stem cell transplantation: a systematic review and meta-analysis.

This systematic reviewand meta-analysisaimed to characterize randomized controlled trials (RCTs) of TCT supportive care interventions and examine effects on patient-reported outcomes (PROs).

本系统评价和荟萃分析旨在描述接受TCT支持性护理干预措施的随机对照试验（RCTs），并检查其对患者报告结果（PROs）的影响。

We systematically searched MEDLINE, Embase, CINAHL, PsycInfo, Web of Science, and Cochrane Central Register of Controlled Trials.

我们系统地检索了MEDLINE、Embase、CINAHL、PsycInfo、Web of Science和Cochrane中央控制试验登记册。

Risk of bias was assessed using Cochrane Risk of Bias 2.0.

使用Cochrane风险偏倚2.0评估偏倚风险。

Findings were grouped by intervention and PRO type and synthesized narratively, with exploratory random-effects meta-analyses estimating pooled intervention effects on anxiety, depression, and quality of life (QOL).

研究结果根据干预措施和患者报告结果(PRO)类型进行分组，并通过叙述性综合分析，使用探索性的随机效应元分析估计干预措施对焦虑、抑郁和生活质量(QOL)的综合干预效果。

Fifty-three RCTs (1992-2025) met inclusion criteria.

共有53项随机对照试验(RCTs)（1992-2025年）符合纳入标准。

The search yielded only RCTs of hematopoietic stem cell transplantation (HSCT) recipients, although we included all transplantation and cellular therapies.

搜索结果仅包括了接受造血干细胞移植（HSCT）的随机对照试验（RCTs），尽管我们包含了所有移植和细胞治疗的研究。

Studies varied in sample size (11-711), participant demographics (mean age, 33-63 years; 22%-64% women), and PROs.

研究在样本量（11-711）、参与者人口统计学特征（平均年龄，33-63岁；女性比例，22%-64%）以及患者报告结果（PROs）方面存在差异。

There were 9 intervention categories: cognitive behavioral (n = 5), exercise only (n = 17), expressive helping (n = 2), mind-body/stress management (n = 7), multimodal (exercise plus another modality; n = 6), music/art (n = 12), palliative care (n = 2), positive psychology (n = 1), and self-management/self-efficacy (n = 5).

共有9种干预类别：认知行为疗法（n = 5），仅运动（n = 17），表达性帮助（n = 2），身心/压力管理（n = 7），多模式（运动加上另一种方式；n = 6），音乐/艺术（n = 12），姑息治疗（n = 2），积极心理学（n = 1），自我管理/自我效能（n = 5）。

Interventions were mostly feasible and acceptable, with promising improvements in psychological distress, QOL, and physical outcomes.

这些干预措施大多是可行和可接受的，对心理困扰、生活质量（QOL）和身体结果有显著改善的前景。

Meta-analysisshowed nonsignificant trends toward exercise interventions improving QOL (standardized mean differences [SMD], 0.09) and music/art interventions reducing acute depressive symptoms (SMD, -0.26).

荟萃分析显示，运动干预在改善生活质量方面呈现非显著趋势（标准化均数差异[SMD]，0.09），音乐/艺术干预在减少急性抑郁症状方面呈现非显著趋势（SMD，-0.26）。

Among patients undergoing HSCT for hematologic malignancies, supportive care interventions show feasibility, acceptability, and promise for improving PROs.

在进行造血干细胞移植（HSCT）治疗血液恶性肿瘤的患者中，支持性护理干预显示出可行性、可接受性，并有望改善患者报告的结果(PROs)。

However, larger, rigorously designed RCTs using standardized PRO measures are needed to establish efficacy.

然而，需要更大规模、设计严谨的随机对照试验（RCTs），使用标准化的患者报告结果（PRO）测量方法来确定疗效。